전남대학교

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김정선 이미지
성명
김정선 교수
연구실
자연과학대 5호관 707호
교수전공 및 연구분야
생화학
연락처
(062)530-3384
이메일
jsunkim@chonnam.ac.kr
홈페이지
http://altair.jnu.ac.kr/~xraylab GO
Major & Degree

Major : Biochemistry, Structural Biology

Degree : Technical University of Munich

Education

1997.2  Seoul National University Food Science and Technology B.S.

1999.2  Pohang University of Science and Technology (POSTECH), Life Science M.S.

2002.9  Technical University of Munich, Chemistry Ph.D.

Experience
2005.9 ~           Chonnam National University; Dept. of Chemistry; Assistant Professor
2005.1 ~ 2005.8     Korea Research Institute of Biosci. and Biotech. (KRIBB) Senior Scientist
2003.12 ~ 2004.12   UC, Berkeley; Department of Chemistry; Postdoc
2002.10 ~ 2003.11   Max-Planck-Institute of Biochemistry; Postdoc
1999.7 ~ 2002.9     Max-Planck-Institute of Biochemistry; Ph.D. candidate
Research Interests

 I am using X-ray crystallography to understand the molecular mechanism of protein functions at the atomic level. Present research directions are focused on DNA-binding proteins and protein degrading system.

Publications
29. Crystal structure of Escherichia coli MazG, the regulator of nutritional stress response Lee S, Kim M, Kang B, Jeong-Sun Kim, Kim KH, Kim YG & Kim KJ J. Biol. Chem. May 30, 2008, 283(22), 15232-15240

28. Crystal structure of single domain VL of an anti-DNA binding antibody 3D8 scFv and its active site revealed by complex structures of a small molecule and metals. Park SY, Lee WR, Lee SC, Kwon MH, Kim YS and Jeong-Sun Kim (corresponding author)Proteins: Structure, Function and Bioinformatics. Jun. 2008, 71(4), 2091-2096

27. Crystal structure of a minimal nitroreductase, ydjA, from Escherichia coli K12 with and without FMN cofactor. Choi JW, Lee J, Nishi K, Kim YS, Jung CH & Jeong-Sun Kim  (corresponding author)
J. Mol. Biol. March 14 2008, 377(1), 258-267.

26. High resolution structure of ybfF from Escherichia coli K12: a unique substrate-binding crevice generated by domain arrangement.
Park SY, Lee SH, Lee J, Nishi K, Kim YS, Jung CH & Jeong-Sun Kim (corresponding author)
J. Mol. Biol. March 7 2008, 376(5), 1426-1437.

25. Crystal structure and domain characterization of ScpB from Mycobacterium tuberculosis.
Jeong-Sun Kim, Lee S, Kang B, Kim M, Lee HS, and Kim KJ
Proteins: Structure, Function and Bioinformatics. May 15 2008, 71(13), 1553-1556.

24. Crystallization and preliminary X-ray diffraction analysis of ydjA, a minimal nitroreductase from Escherichia coli K12.
Choi JW, Lee J, Nishi K, Jung CH and Jeong-Sun Kim. (corresponding author)
Acta Crystallogr., Sect. F (Dec. 2007), 63(12), 1064-1066

23. Crystallization and preliminary X-ray diffraction analysis of ybfF, a new esterase from Escherichia coli K12.
Park SY, Lee SH, Lee J, Jung CH and Jeong-Sun Kim (corresponding author)
Acta Crystallogr., Sect. F (Dec. 2007), 63(12), 1051-1053.

22. Inducing rigid local structure around the zinc-binding region by hydrophobic interactions enhances the homotrimerization and apoptotic activity of zinc-free TRAIL.
Lee HW, Kim TI, Chan KH, Kwon MH, Jeong-Sun Kim, Jin MS and Kim YS
Biochemical and Biophysical Research Communications Oct. 26 2007 362(3). 766-772.

21. Construction and characterization of a pseudo-immune human antibody library using yeast surface display.
 Lee HW, Lee SH, Park KJ, Jeong-Sun Kim, Kwon MH and Kim YS (2006)
Biochemical and Biophysical Research Communications 2006 Aug. 4; 346(3): 896-903.

20. Heavy and light chain variable single domains of an anti-DNA binding antibody hydrolyze both double- and single-stranded DNAs without sequence specificity.
Kim YR, Jeong-Sun Kim*, Lee SH, Lee WR, Sohn JN, Chung YC, Shim HK, Lee CH, Kwon MH#, Kim YS# (*correspondence on crystallography, #cocorresponding authors).
J. Biol. Chem. 2006 Jun 2;281(22):15287-15295.

19. Crystal structure of the DUF16 domain of MPN010 from Mycoplasma pneumoniae.
Shin, D. -H., Jeong-Sun Kim, Yokota, H, Kim, R., Kim, S.H.
Protein Sci. 2006  Apr;15(4):921-8.

18. Crystal structure of ScpB from Chlorobium tepidum, a protein involved in chromosome partitioning.
Jeong-Sun Kim, Shin DH, Pufan R, Huang C, Yokota H, Kim R, Kim SH
Proteins: Structure, Function and Bioinformatics. Feb. 1, 2006, 62(2); 322-328.

17. Structural Genomics of Minimal Organisms and Protein Fold Space.
Kim SH, Shin DH, Liu J, Oganesyan V, Chen S, Xu QS, Jeong-Sun Kim, Das D, Schulze-Gahmen U, Holbrook SR, Holbrook EL, Martinez BA, Oganesyan N, DeGiovanni A, Lou Y, Henriquez M, Huang C, Jancarik J, Pufan R, Choi IC, Chandonia JM, Hou J, Gold B, Yokota H, Brenner SE, Adams PD, Kim R.
J. Struct. Funct. Genomics 2005 Sept.;6(2-3):63-70.

16. X-ray Snapshots of Peptide Processing in Mutants of Tricorn Interacting Factor F1 from Thermoplasma acidophilium
Goettig P, Brandstetter H, Groll M, Goehring W, Konarev PV, Svergun DI, Huber R, Jeong-Sun Kim (corresponding author)
J. Biol. Chem., 2005 September 30, 280(39):33387-33396.

15. Crystal Structure of a Heat-Inducible Transcriptional Repressor Hrca from Thermotoga Maritime.
Liu J, Huang C, Shin DH, Yokota H, Jancarik J, Jeong-Sun Kim, Adams PD, Kim R, Kim SH
J. Mol. Biol. July 29, 2005: 350(5):987-996.

14. Crystal structure of DNA sequence specificity subunit of a type I restriction-modification enzyme and its functional implications.
Jeong-Sun Kim, Giovanni AD, Jancarik J, Adams PD, Yokota H, Kim R, Kim SH
PNAS USA, March 1, 2005: 102(9):3248-3253.

13. Crystal structure of fervidolysin from Fervidobacterium pennivorans, a keratinolytic enzyme related to subtilisin
Jeong-Sun Kim, Kluskens L, de Vos WM., Huber R, van der Oost J (corresponding author)
J. Mol. Biol. 2004 Jan 16;335(3):787-797.

12. Expansion of the Genetic Code Enables Design of a Novel “Gold” Class of Green Fluorescent Proteins
Bae JH, Rubini M, Jung G, Wiegand G, Seifert MHJ, Azim MK, Jeong-Sun Kim, Zumbusch A, Holak TA, Moroder L, Huber R, Budisa N
J. Mol. Biol. 2003 May 16:328(5):1071-1081.

11. Navigation inside a protease: substrate selection and product exit in the tricorn protease from Thermoplasma acidophilum
Jeong-Sun Kim, Groll M, Musiol HJ, Behrendt R, Kaiser M, Moroder L, Huber R, Brandstetter H (corresponding author)
J. Mol. Biol. 2002 Dec 13;324(5):1041-1050.

10. Structures of the tricorn-interacting aminopeptidase F1 with different ligands explain its catalytic mechanism. 
Goettig P, Groll M, Jeong-Sun Kim, Huber R, Brandstetter H
EMBO J. 2002 Oct 15;21(20):5343-5352.

9. Structural Basis for the Processive Protein Degradation by Tricorn Protease.
Brandstetter H, Jeong-Sun Kim, Groll M, G?ttig P, Huber R
Biol. Chem. 2002, July/August: 383: 1157-1165.

8. Crystal structure of the tricorn protease reveals a protein disassemly line.
Jeong-Sun Kim, Brandstetter H, Groll M, Huber R
Nature 2001, November 22; 414(6862):466-470.

7. Role of Glutamate 332 Residue in the Transglycosylation Activity of Thermus Maltogenic Amylase.
Kim TJ, Park CS, Cho HY, Cha SS, Jeong-Sun Kim, Lee SB, Moon TW, Kim JW, Oh BH, Park KH
Biochemistry 2000, June 39(23):6773-6780.

6. Contribution of the Hydrogen-Bond Network Involving a Tyrosine Triad in the Active Site to the Structure and Function of a Highly Proficient Ketosteroid Isomerase from Pseudomonas putida Biotype B.
Kim DH, Jang DS, Nam GH, Choi GD, Jeong-Sun Kim, Ha NC, Kim MS, Oh BH, Choi KY
Biochemistry 2000, April 39(16):4581-4589.

5. Roles of active site aromatic residues in catalysis by ketosteroid isomerase from Pseudomonas putida biotype B.
Kim DH, Nam GH, Jang DS, Choi G, Joo S, Jeong-Sun Kim, Oh BH, Choi KY
Biochemistry 1999 Oct 19;38(42):13810-13819.

4. Crystal structure of a maltogenic amylase provides insights into a catalytic versatility.
Jeong-Sun Kim, Cha SS, Kim HJ, Kim TJ, Ha NC, Oh ST, Cho HS, Cho MJ, Kim MJ, Lee HS, Kim JW, Choi KY, Park KH, Oh BH
J. Biol. Chem. 1999 Sep 10;274(37):26279-26286.

3. Determination of the limited trypsinolysis pathways of tumor necrosis factor-alpha and its mutant by electrospray ionization mass spectrometry.
Kim YJ, Cha SS, Jeong-Sun Kim, Shin NK, Jeong W, Shin HC, Oh BH, Hahn JH
Anal. Biochem. 1999 Feb 15;267(2):279-286.

2. High resolution crystal structure of a human necrosis factor-alpha mutant with low systemic toxicity.
Cha SS, Jeong-Sun Kim, Cho HS, Shin NK, Jeong W, Shin HC, Hahn JH, Oh BH
J. Biol. Chem. 1998 Jan 23;273(4):2153-2160.

1. High-resolution crystal structure of delta5-3-ketosteroid isomerase with and without a reaction intermediate analogue.
Kim SW, Cha SS, Cho HS, Jeong-Sun Kim, Ha NC, Cho MJ, Joo S, Kim KK, Choi KW, Oh BH
Biochemistry 1997 Nov 18;36(46):14030-14036.