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성명
이철원 교수
연구실
자연과학대 5호관 706호
교수전공 및 연구분야
생화학
연락처
(062)530-3374
이메일
cwlee@jnu.ac.kr
홈페이지
http://chulwonlee.wixsite.com/mysite GO
Major & Degree

Major : Biochemistry

Degree : GIST, Biochemistry. Ph.D.

Education

1991.3 ~ 1998.2  Chungnam National University, Dept. of Biochemistry, B.S.

1998.3 ~ 2000.2  GIST, Dept. of Life Science M.S.

2000.3 ~ 2004.2  GIST, Dept. of Life Science Ph.D.

Experience

2011.9 ~                Chonnam National University; Dept. of Chemistry; Assistant Professor


2010.7 ~ 2011.8     Indiana University, Dept. of Chemistry, Assistant Scientist
2004.8 ~ 2010.6     The Scripps Research Institute, Dept. of Molecular Biology, Research Associate
2004.3 ~ 2004.7     GIST, Dept. of Life Science, Postdoc
Research Interests

1.   Structure determination of protein and peptide using solution NMR spectroscopy


2.   Protein-protein interaction
3. Structural studies of metalloregulatory proteins
4. Peptide neurotoxin
5. Peptide drug discovery
Publications

21. Lee CW, Giedroc DP. (1)H, (13)C, and (15)N resonance assignments of NmtR, a Ni(II)/Co(II) metalloregulatory protein of Mycobacterium tuberculosis. Biomol NMR Assign. in press


20. Lee CW, Chakravorty DK, Chang FM, Reyes-Caballero H, Ye Y, Merz KM Jr, Giedroc DP. Solution structure of Mycobacterium tuberculosis NmtR in the apo state: insights into Ni(II)-mediated allostery. Biochemistry. 2012 Mar 27; 51(12): 2619-2629.
19. Lee CW, Bae C, Lee J, Ryu JH, Kim HH, Kohno T, Swartz KJ, Kim JI. Solution structure of kurtoxin: a gating modifier selective for Cav3 voltage-gated Ca2+channels. Biochemistry. 2012 Mar 6; 51(9):1862-1873.
18. Lee CW, Eu YJ, Min HJ, Cho EM, Lee JH, Kim HH, Nah SY, Swartz KJ, Kim JI. Expression and characterization of recombinant kurtoxin, an inhibitor of T-type voltage-gated calcium channels. Biochem Biophys Res Commun. 2011 Dec 16; 416(3-4): 277-282.
17. Chakravorty DK, Wang B,Lee.C.W., Giedroc DP, Merz KM. Simulations of Allosteric Motions in the Zinc Sensor CzrA. J. Am. Chem. Soc. 2012 Feb 22; 134(7): 3367-3376
16. Reyes-Caballero H, Lee,C.W., and Giedroc D.P. Mycobacterium tuberculosis NmtR harbors a nickel sensing site with parallels to Escherichia coli RcnR and Streptomyces coelicolor Ni(II)-superoxide dismutase. Biochemistry ( 2011) Sep 20; 50(37): 7941-7952
15. Lee,C.W., Li, L, and Giedroc, D.P. The solution structure of coronaviral stem-loop 2 (SL2) reveals a canonical CUYG tetraloop fold. FEBS Letters (2011) Apr. 6; 585(7): 1049-1053.
14. Dragnea, V., Arunkumar, A., Lee,C.W., Giedroc, P.D., Bauer, C. A. A Q63E Rhodobacter sphaeroides AppA BLUF domain mutant is locked in a pseudo-light-excited signaling state. Biochemistry, (2010) Dec 21; 49(50): 10682-10690
13. Lee,C.W., Ferreon, J.C., Ferreon A.C., Arai, M., and Wright, P.E. Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation. Proc. Natl. Acad. Sci. USA, (2010) Nov. 9; 107(45): 19290-19295.
12. Lee,C.W., Martinez-Yamout, A.M., Dyson, H.J., and Wright, P.E. Structure of the p53 Transactivation Domain in Complex with the Nuclear Receptor Coactivator Binding Domain of CREB Binding Protein. Biochemistry (2010) Nov 23; 49(46): 9964-9971.
11. Jung H.H., Jung H.J., Milescu M., LeeC.W., Lee S., Lee J.Y., Eu Y.J., Kim H.H., Swartz K.J., Kim J.I. Structure and orientation of a voltage-sensor toxin in lipid membranes. Biophys J. (2010) Jul 21; 99(2): 638-46.
10. Lee S., Milescu M., Jung H.H., Lee J.Y., Bae C.H., LeeC.W., Kim H.H., Swartz K.J., Kim J.I. Solution structure of GxTX-1E, a high-affinity tarantula toxin interacting with voltage sensors in Kv2.1 potassium channels. Biochemistry. (2010) Jun 29; 49(25): 5134-42
9. Ferreon, J.C.*, Lee,C.W.*, Arai, M., Martinez-Yamout, A.M., Dyson, H.J., and Wright, P.E. Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2. Proc. Natl. Acad. Sci. USA (2009) Apr. 21 106 (16), 6591-6596.
8. Lee,C.W., Arai, M., Martinez-Yamout, A.M., Dyson, H.J., and Wright, P.E. Mapping the interactions of the p53 transactivation domain with the KIX domain of CBP. Biochemistry (2009) Mar. 17 48 (10), 2115?2124.
7. Lee, J.Y., Moon, J.S., Eu, Y.J., Lee,C.W., Yang, S-T, Lee, S.K., Jung, H.H., Kim, H.H., Rhim, H., Seong, J.Y., Kim, J.I. Molecular interaction between kisspeptin decapeptide analogs and a lipid membrane. Arch Biochem Biophys. (2009) May 15 485(2), 109-114.
6. Jung, H.J., Kim, P.I., Lee, S.K., Lee,C.W., Eu, Y.J., Lee, D.G., Earm, Y.E., and Kim, J.I. Lipid membrane interaction and antimicrobial activity of GsMTx-4, an inhibitor of mechanosensitive channel. Biochem Biophys Res Commun. (2006) 340(2), 633-638.
5. Wang, J.M., Roh, S.H., Kim, S., Lee,C.W., Kim, J.I., and Swartz, K.J. Molecular surface of tarantula toxins interacting with voltage sensors in K(v) channels. J. Gen. Physiol. (2004) 123, 455-467. 0022-1295
4. Lee,C.W., Kim, S., Roh, S.H., Endoh, H., Kodera, Y., Maeda, T., Kohno, T., Wang, J.M., Swartz, K.J., and Kim, J.I. Solution structure and functional characterization of SGTx1, a modifier of Kv2.1 channel gating. Biochemistry (2004) 43, 890-897. 0006-2960
3. Lee,C.W., Lee, E.H., Takeuchi, K., Takahashi, H., Shimada, I., Sato,K., Shin,S.Y., Kim,D.H., and Kim,J.I. Molecular basis of the high-affinity activation of type1 ryanodinereceptors by imperatoxin A. Biochem. J. (2004) 377, 385-394. 1470-8728
2. Yang, S.T., Shin, S.Y., Lee,C.W., Kim, Y.C., Hahm, K.S., and Kim, J.I. Selective cytotoxicity following Arg-to-Lys substitution in tritrpticin adopting a unique amphipathic turn structure. FEBS Lett. (2003) 540, 229-233.
1. Takeuchi, K., Park, E.J., Lee,C.W., Kim, J.I., Takahashi, H., Swartz, K.J., and Shimada, I. Solution structure of omega-grammotoxin SIA, a gating modifier of P/Q and N-type Ca2+channel. J. Mol. Biol. (2002) 321, 517-526.